小公司的大梦想：盘点这两年热门的新药研发技术平台

企业	技术平台	技术应用	主要合作伙伴
IsisPharma	antisensetechnology	以RNA为靶点的反义药物	BiogenIdec, Genzyme, GlaxoSmithKline, AstraZeneca, Roche
SeattleGenetics	ADCtechnology	抗体偶联药物	Genentech,Pfizer, Abbvie, Bayer, GlaxoSmithKline, Takeda, DaiichiSankyo
ImmunoGen	TAPtechnology	抗体偶联药物	Genentech,Bayer, Amgen,  Lilly, Sanofi,Novartis
BindTherapeutics	Accurins	靶向载药纳米粒	Amgen,Pfizer, AstraZeneca
Ambrx	proteinmedicinal chemistry	蛋白质精确修饰，抗体偶联药物	Bristol-MyersSquibb, Merck, Astellas
SantarisPharma	LNA drugplatform	以RNA为靶点的锁核酸药物	Bristol-MyersSquibb, Pfizer, GlaxoSmithKline, Shire
Immunocore	ImmTACtechnology	单克隆TCR	Genentech,GlaxoSmithKline
ArrayBioPharma	Arraydiscovery platform	小分子药物发现及前期开发	AstraZeneca,Genentech, Novartis
AstexPharma	fragment-baseddrug discovery	基于碎片发现小分子药物	Novartis,Janssen, AstraZeneca, GlaxoSmithKline
Ablynx	Nanobodytechnology	单域迷你抗体	AbbVie,Boehringer Ingelheim, Merck Serono, Merck, Novartis
InovioPharma	syntheticDNA vaccines	合成的DNA疫苗	Roche, VGXInternational, NIH/NIAID
MolecularPartners	DARPinplatform	人工设计锚蛋白	Janssen,Allergan, Centocor, Roche
EvotecAG	drugdiscovery solutions	靶点确证与药物发现	Bayer,Boehringer Ingelheim, Genentech, Janssen, AstraZeneca
EnsembleTherapeutics	DNA-programmedchemistry	大环肽类药物	Novartis,Bristol-Myers Squibb, Genentech, Boehringer Ingelheim,Alexion
CoNCERTPharma	DCEPlatform	氘代药物	GlaxoSmithKline,Celgene, Avanir Pharma, Jazz Pharma
Genmab	DuoBodytechnology	双靶点抗体	Novartis,Janssen, Kyowa Hakko Kirin
Adimab	Yeast-basedscreening system	全人源抗体高速筛选优化	GlaxoSmithKline,Lilly, Merck, Novartis, Pfizer, Roche, Celgene, Biogen Idec,Gilead
AlnylamPharma	RNAiplatform	RNAi药物	Takeda,Genzyme, Novartis, Biogen Idec, GlaxoSmithKline,AstraZeneca
Depomed	Acuformdelivery technology	缓控释制剂	Janssen,Covidien, Boehringer Ingelheim, Merck
FormaTherapeutics	industrializeddiscovery engine	小分子抗癌药物的发现	Celgene,Janssen, Boehringer Ingelheim, Genentech, EISAI Pharma,Novartis
XenonPharma	ExtremeGenetics discovery platform	基于临床遗传学的药物发现	Merck,Genentech, Teva
BioInvent International	n-CoDeRantibody library	抗体筛选	Bayer,Daiichi Sankyo, Mitsubishi Tanabe, Servier
HalozymeTherapeutics	ENHANZEtechnology	生物制品皮下注射给药技术	Roche,Baxter Healthcare, Pfizer, ViroPharma

注：AstexPharma已于今年9月被OtsukaPharma收购。