In clinical trials for rheumatoid arthritis, standard criteria to compare the effectiveness of various arthritis medications or arthritis treatments, or to compare one trial to another trial has become widely used. The criteria, known as ACR Criteria or American College of Rheumatology Criteria, is referred to in nearly all published studies assessing efficacy.
ACR criteria is indicated as ACR20, ACR50, and ACR70. ACR criteria measures improvement in tender or swollen joint counts and improvement in three of the following five parameters:
Clinical trials report the percentage of study participants who achieve ACR20, ACR50, and ACR70. For example, if a study reported that 55 percent of patients achieved ACR20, that means 55 percent of patients in the study achieved a 20 percent improvement in tender or swollen joint counts as well as 20 percent improvement in three of the other five criteria.
If a clinical trial reports that 40 percent of patients achieved ACR50, that means 40 percent of patients in the study achieved a 50 percent improvement in tender or swollen joint counts as well as 50 percent improvement in three of the other five criteria. For patients to be assessed using ACR criteria, they must have completed the trial.
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