热心肠日报

Nature

[IF:40.137]

Salt-responsive gut commensal modulates TH17 axis and disease

DOI: 10.1038/nature24628

Abstract & Authors   展开

Abstract:
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased TH17 cells and increased blood pressure. Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions.

First Authors:
Nicola Wilck

Correspondence:
Eric J Alm, Dominik N Müller

All Authors:
Nicola Wilck , Mariana G Matus , Sean M Kearney , Scott W Olesen , Kristoffer Forslund , Hendrik Bartolomaeus , Stefanie Haase , Anja Mähler , András Balogh , Lajos Markó , Olga Vvedenskaya , Friedrich H Kleiner , Dmitry Tsvetkov , Lars Klug , Paul I Costea , Shinichi Sunagawa , Lisa Maier , Natalia Rakova , Valentin Schatz , Patrick Neubert , Christian Frätzer , Alexander Krannich , Maik Gollasch , Diana A Grohme , Beatriz F Côrte-Real , Roman G Gerlach , Marijana Basic , Athanasios Typas , Chuan Wu , Jens M Titze , Jonathan Jantsch , Michael Boschmann , Ralf Dechend , Markus Kleinewietfeld , Stefan Kempa , Peer Bork , Ralf A Linker , Eric J Alm, Dominik N Müller

2017-11-15Article

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