图片来自于文献2,应激引起炎症反应的利与弊
总的来说,本文通过细致的研究阐述了应激诱导的IL-6对机体功能的机制:急性应激引起交感神经输出,激活肾上腺素受体3后促进IL-6水平的升高,随后增强肝脏合成葡萄糖的能力,为逃避或战斗储备能量。
参考文献:
1. LeMay, L.G., Vander, A.J., and Kluger, M.J. (1990). The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47, 957–961
2. Qing et al., Origin and Function of Stress-Induced IL-6 in Murine Models, Cell (2020), https://doi.org/10.1016/j.cell.2020.05.054
3. Hunter, C.A., and Jones, S.A. (2015). IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16, 448–457
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