植物通过对非生物胁迫的防御来适应不利的环境，这主要是由植物激素脱落酸（ABA）调控的。但是ABA的稳态是如何被调节来平衡生长和应激反应的仍然是个未知数。本文报道了高铜处理对拟南芥幼苗生长的抑制作用，但通过调节ABA的积累提高了拟南芥幼苗后期的耐旱性。随后的遗传学、生理学、转录组学和分子生物学研究表明，铜反应性转录因子启动子SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 7 结合蛋白-7（SPL7）是ABA积累的强调节因子。我们发现SPL7被高铜破坏，并通过与启动子中的GTAC铜反应基序结合，持续抑制陆地植物ABA生物合成途径中编码三种关键加氧酶的基因。这些结果揭示了一种新的机制，即铜的有效性与SPL7丰度相反，调节ABA的从头合成，以平衡生长和耐旱性。
Plants adapt to adverse environments by turning on defense against abiotic stresses, which is mainly orchestrated by the phytohormone abscisic acid (ABA). But how ABA homeostasis is modulated to balance growth and stress responses is still largely unknown. Here we report that prior treatment of Arabidopsis seedling with high copper retardates growth but enhances draught tolerance at later stages by modulating ABA accumulation. Subsequent genetic, physiological, transcriptomic, and molecular investigations revealed that the copper responsive transcription factor SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 7 (SPL7) is a strong regulator of ABA accumulation. We showed that SPL7 is destabilized by high copper and consistently suppresses genes encoding three key oxygenases in the ABA biosynthetic pathway of land plants via binding to the GTAC copper response motifs in their promoters. These results revealed a new mechanism whereby copper availability, inversely reflected by SPL7 abundance, modulates de novo ABA biosynthesis to balance growth and drought tolerance.
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