As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring.
随着男性精子生产能力降低，拥有Y染色体精子的比例亦减少。因此，男性的生殖潜力可能预测他获得男性后代的能力。
In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations.
近年来，调查研究者注意到许多工业化国家出现男性出生比例下降的趋势。
While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio.
尽管男性承载着决定性别的染色体（Y染色体--译注），承担受精或流产的女性伴侣也可能发挥改变性别比例的角色。
We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm.
通过直接检查男性精子决定性别的染色体，我们试图确定一位男性后代的性别比例（第一代）。
We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH).
我们对我们男性不育临床数据库中所有做过精液荧光原位杂交（FISH）的男性数据进行了审查。
Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios (Y chromosomes/total chromosomes). Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters.
对不育患者的人口统计资料与精液参数进行了记录。采用卡方分析用来做比较性别比（Y染色体/总染色体）。采用多变量逻辑回归来预测考虑了人口统计资料与精液参数后的拥有Y染色体精子的几率。
A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6%; P=0.02).
总共184位男性进行了精液荧光原位杂交（FISH）。对185位男性整个群体而言，拥有Y染色体精子的比例为51.5%。然而，精液中精子数量少于500万个活动精子的男性，他们拥有的Y染色体精子的比例（50.8%）统计意义低于精子数量更高的男性（51.6%; P=0.02）。
After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01).
多变量调整后揭示，精子浓度更高、总活动性精子数量与精液量统计意义增高拥有Y染色体精子的机会（P<0.01）。
As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring.
结论：随着男性精子生产能力降低，拥有Y染色体精子的比例亦减少。因此，男性的生殖潜力可能预测他获得男性后代的能力。
Eisenberg ML et al., Sperm counts and sperm sex ratio in male infertility patients,Asian J Androl. 2012 Sep;14(5):683-6. Epub 2012 Jul 30.
Eisenberg ML et al.，男性不育患者中的精子数量与精子性别比，亚洲男科杂志，2012年9月；14(5):683-6.。上网发布：2012年7月30日
http://www.babymed.com/abstracts/sperm-counts-and-sperm-sex-ratio-male-in-infertility-patients
Department of Urology, Stanford University School of Medicine, Stanford, USA.
美国斯坦福大学医学院泌尿系
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