IgG1/IgG2a来评价疫苗诱导的免疫应答

 这一般是评价疫苗诱导的应答是偏向于Th1还是Th2型（为Th细胞的两个分化方向，Th1可以分泌多种细胞因子如干扰素促进CTL反应即所谓的细胞免疫倾向，而Th2则可以分泌细胞因子IL-4促进抗体产生即所谓的体液免疫倾向，当然这两种方向只是偏向而已）
在小鼠体内，Th1型会产生IgG2a型抗体，Th2型则会产生IgG1型抗体。但是在人体内则是相反的。
所以我们经常会用IgG1/IgG2a来评价疫苗诱导的免疫应答是偏向于哪种应答！

 

BALB/c mice typically respond to vaccines and subunit vaccines with a Th2-type immune response, which is associated with the stimulation of IgG1 antibodies . However, the major antibody isotype present in the sera of mice that survive viral infections is IgG2a , which is stimulated during Th1-type immune responses . Stimulation of IgG2a antibodies has been associated with increased efficacy of  vaccination . Additionally, monoclonal antibodies of the IgG2a isotype are more efficient at clearing  virus infections than monoclonal antibodies of the IgG1 isotype displaying similar antigenic specificities.

 

BALB/C鼠对疫苗的的典型应答是与IgG2a抗体相关的TH2型免疫应答。然而，存在于病毒感染的鼠血清中的主要抗体同种型是IgG2a抗体，是Th1 型免疫应答分泌的。刺激IgG2a抗体与疫苗的有效性正相关。另外，IgG2a单克隆抗体在清除病毒感染上比IgG1抗体更有效。