也就是说,香烟烟雾暴露导致肠道菌群丰度和组成的改变仅是第一步,但会产生“多米诺效应”——引发肠道菌群代谢物的改变,进一步导致肠道屏障功能受损以及致癌性MAPK/ERK信号传导,最终诱发结直肠癌。为了证明香烟烟雾确实引发小鼠肠道菌群的失调,研究者还增加了一步——将暴露于香烟烟雾组小鼠的肠道微生物群移植至常规小鼠体内。同样,得到了相似的结果,即导致肠道屏障的损伤与致癌MAPK/ERK通路的增强,增加被移植小鼠发生结直肠肿瘤的可能性。这项研究表明,吸烟会导致肠道微生物群组成的改变,进而诱发结直肠癌。相反与继续吸烟者相比,戒烟可以有效提高结直肠癌的特异性生存率。因此,研究者认为,戒烟能够重建健康的肠道菌群,是预防结直肠癌的实用方法之一。众所周知,吸烟有害健康。但对于烟草依赖的人来说,戒烟的确不是一件容易的事儿。鉴于今天是世界无烟日,不如就从今天开始,从逐渐减少到最终远离,珍惜自己和身边人的身体健康。参考资料[1]Bai X, Wei H, Liu W, et alCigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolitesGut Published Online First: 06 April 2022. doi: 10.1136/gutjnl-2021-325021[2]Li N, Wu P, Wang Z, Shen Y, Zhang L, Xue F, Han W, Chen Y, Du J, Zhao Y, Yang C, Hu Y, Gu W, Chen W, Guo X, Liu B, Jiang J, Xu N. Smoking-related cancer death among men and women in an ageing society (China 2020-2040): a population-based modelling study. Tob Control. 2021 Nov 1:tobaccocontrol-2020-056444. doi: 10.1136/tobaccocontrol-2020-056444. Epub ahead of print. PMID: 34725269.[3]Liu Z, Li YH, Cui ZY, Li L, Nie XQ, Yu CD, Shan GL, Zhou XM, Qin R, Cheng AQ, Chung KF, Chen ZM, Xiao D, Wang C. Prevalence of tobacco dependence and associated factors in China: Findings from nationwide China Health Literacy Survey during 2018-19. Lancet Reg Health West Pac. 2022 May 4;24:100464. doi: 10.1016/j.lanwpc.2022.100464. PMID: 35538934; PMCID: PMC9079698.