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Highlight of the month
Nanotech that goes with the flow

© KATERYNA KON/Science Photo Library/Getty
Combining nanoscience with ‘lab-on-a-chip’ technology could enhance the efficacy and safety of a new form of therapeutics, a study led by University of South Australia researchers suggests.南澳大利亚大学(University of South Australia)研究人员领导的一项研究表明，将纳米科学与“芯片上的实验室”(lab-on-a-chip)技术相结合，可能会提高一种新型疗法的有效性和安全性。
Nanoparticles show great promise as drug delivery vehicles, able to ferry medicine directly into target cells.纳米颗粒作为药物传递载体，能够将药物直接运送到靶细胞中，前景广阔 Chemists are becoming increasingly adept at tuning nanoparticle parameters such as shape, size and surface chemistry.化学家们越来越擅长调整纳米颗粒的形状、大小和表面化学等参数However, the range of potential nanoparticle formulations has become so large is it difficult to identify the best one for a given task.
Craig Priest, Nicolas Voelcker, and their colleagues have shown how shrinking nanoparticle cell toxicity testing on to a miniaturized device can speed up the process.他们的同事已经展示了缩小纳米颗粒细胞毒性测试在小型化设备上是如何加速这一过程的Using a credit card sized microfluidic chip, they flowed various nanoparticles over living cells to assess particle toxicity.使用信用卡大小的微流控芯片，他们将各种纳米颗粒流到活细胞上，以评估颗粒毒性 The chip’s multiple inlets and outlets allowed up to five nanoparticles to be tested simultaneously. 芯片的多个入口和出口允许多达5个纳米颗粒同时进行测试。
The team is now scaling up the chip design, to be able to test multiple nanoparticles against multiple cell types in a single experiment. 该团队现在正在扩大芯片设计，以便能够在一次实验中测试多个纳米颗粒与多个细胞类型的对比。
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Analytical Chemistry 90, 4338–4347
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