【罂粟摘要】抗胆碱能药物对全麻下气管插管患者视力的影响

抗胆碱能药物对全麻下气管插管患者视力的影响

 

贵州医科大学  麻醉与心脏电生理课题组

翻译：严旭   编辑：潘志军   审校：曹莹

背景：

全身麻醉（GA）是手术干预的核心手段，主要用于镇痛和缓解焦虑。因此，有必要了解GA诱导期间的实验室和临床研究结果。盐酸苯海拉明（PHCD）联合硫酸阿托品（Atr）有可能诱导GA。然而，盐酸苯海拉明联合硫酸阿托品在全身麻醉下气管插管时的作用仍不清楚。

方法

：

本研究回顾性地招募了473名在GA诱导下进行手术的患者，根据术前使用盐酸苯海拉明（有或没有），将他们分为研究组（n = 234）和对照组（n = 239）。两组患者术后均给予硫酸阿托品和护理干预。观察并比较两组的麻醉相关指数、不良反应和血液动力学。

结果：

研究组和对照组在麻醉相关指标和血流动力学方面没有显著差异。研究组的视力模糊和复视的发生率比对照组高。

结论:

在临床实践中应避免术前盐酸苯海拉明联合术后硫酸阿托品，或术前应使用硫酸阿托品而非盐酸苯海拉明，以减少视力模糊、复视和其他不良反应的发生。

原始文献来源：

Jinmei Song, Wenchao Shen, Yi Cheng,  and Yunhui Zhengcorresponding author

Effects of Anticholinergic Drugs on Visual Acuity of Patients with Tracheal Intubation under General Anesthesia .Dis Markers. 2022; 2022: 4559547. Published online 2022 Jun 20. doi: 10.1155/2022/4559547 PMCID: PMC9236765PMID: 35769814

罂粟花

Effects of Anticholinergic Drugs on Visual Acuity of Patients with Tracheal Intubation under General Anesthesia

Abstract：

Background：

General anesthesia (GA) is the core means of surgical intervention, mainly used for analgesia and anxiety relief. Therefore, it is necessary to understand the laboratory and clinical research results during induction of GA. Penehyclidine hydrochloride (PHCD) combined with atropine sulfate (Atr) has the potential to induce GA. However, the role of PHCD combined with Atr during tracheal intubation under GA remains unclear.

Methods：

This study retrospectively enrolled 473 patients who underwent surgery under GA induction and divided them into a research group (n = 234) and a control group (n = 239) according to preoperative use of PHCD (with or without). Both groups of patients were given Atr postoperatively and nursing intervention. Anesthesia-related indexes, ARs, and hemodynamics were observed and compared between the two groups.

Results：

There were no significant differences in anesthesia-related indexes and hemodynamics between the research group and the control group. The incidence of blurred vision and diplopia in the research group was higher than that in the control group.

Conclusion：

Preoperative PHCD combined with postoperative Atr should be avoided in clinical practice, or Atr rather than PHCD should be used preoperatively, so as to reduce the occurrence of blurred vision, diplopia, and other ARs.

END