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Cardiorespiratory effects of epidural anesthesia using lidocaine with morphine or dexmedetomidine in capuchin monkeys (Sapajus sp.) undergoing bilateral tubal ligation surgery, anesthetized with isoflurane
背景与目的
硬膜外麻醉可以减少其他麻醉要求，延长镇痛，并减少副作用。在灵长类动物中，它的使用很少被描述。本实验的目的是评价使用利多卡因与吗啡（MOR）或右美托咪定（DEX）的硬膜外麻醉对心肺影响。
方 法
十只雌性卷尾猴在全身麻醉下接受利多卡因和DEX或MOR的硬膜外麻醉
结 果
在所有组中血压显着降低，在DEX组中心率降低，SpO2没有变化。 随着时间的推移，直肠温度显着降低。 观察到稳定的心律; 然而，在DEX组中有一个长久的QT间期。
结 论
腰骶部的硬膜外麻醉是安全和容易实施的。 DEX降低心率。 在所有组中 均促进了直肠温度的降低和呼吸与心律的平稳; 然而，低血压应该被考虑到。
原始文献摘要
Schäffer DPH, Araujo NLLC,Otero AR, et al. Cardiorespiratory effects of epidural anesthesia using lidocaine with morphine or dexmedetomidinein capuchin monkeys (Sapajus sp.) undergoing bilateral tuballigation surgery, anesthetized with isoflurane. J Med Primatol.2017;00:1–9.DOI: 10.1111/jmp.12304
Background: Epidural anesthesia is indicated to decrease other anesthetic requirements, prolong analgesia, and reduce side effects. In primates, its use has been scarcely described. The aim was to evaluate the cardiorespiratory effects of epidural anesthesia with lidocaine and dexmedetomidine (DEX) or morphine (MOR).
Methods: Ten female capuchin monkeys (Sapajus sp.) received epidural anesthesia with lidocaine and DEX or MOR under general anesthesia.
Results: There was a significant decrease in heart rate with DEX and in blood pressure in all groups, with no changes in SpO2. There was a significant reduction in rectal tem-perature over time. A stable cardiac rhythm was observed; however, there was a pro-longed QT interval with DEX.
Conclusions: Epidural anesthesia with access to the lumbosacral space was safe and easy to perform. DEX decreased heart rate. All groups promoted a decrease in rectal temperature with respiratory and cardiac rhythm stability; however, hypotension should be considered
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