Affected Systems
digestive/alimentary system
√ stomach inflammation
√ endocrine/exocrine glands
√ √ √ √ √ √ √ √ √ √ small thymus
√ √ √ decreased thymocyte number
√ √ √ √ abnormal thymocyte activation
√ abnormal pancreas physiology
√ periinsulitis
√ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ small thymus
√ √ √ decreased thymocyte number
√ √ √ √ abnormal thymocyte activation
√ abnormal T cell differentiation
√ √ √ √ √ √ √ abnormal negative T cell selection
√ √ √ √ √ √ √ √ abnormal positive T cell selection
√ √ abnormal double-negative T cell morphology
√ √ abnormal double-positive T cell morphology
√ √ decreased double-positive T cell number
√ √ √ arrested T cell differentiation
√ decreased hematocrit
√ decreased CD4-positive, alpha beta T cell number
√ √ √ decreased CD8-positive, alpha-beta T cell number
√ √ √ increased CD8-positive, alpha-beta T cell number
√ spleen hypoplasia
√ abnormal immunoglobulin level
√ √ abnormal cytotoxic T cell physiology
√ decreased T cell proliferation
√ increased T cell proliferation
√ √ decreased physiological sensitivity to xenobiotic
√ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ stomach inflammation
√ small thymus
√ √ √ decreased thymocyte number
√ √ √ √ abnormal thymocyte activation
√ periinsulitis
√ abnormal T cell differentiation
√ √ √ √ √ √ √ abnormal negative T cell selection
√ √ √ √ √ √ √ √ abnormal positive T cell selection
√ √ abnormal double-negative T cell morphology
√ √ abnormal double-positive T cell morphology
√ √ decreased double-positive T cell number
√ √ √ arrested T cell differentiation
√ decreased CD4-positive, alpha beta T cell number
√ √ √ decreased CD8-positive, alpha-beta T cell number
√ √ √ increased CD8-positive, alpha-beta T cell number
√ spleen hypoplasia
√ abnormal immunoglobulin level
√ √ abnormal cytotoxic T cell physiology
√ decreased T cell proliferation
√ increased T cell proliferation
√ abnormal cytokine secretion
√ decreased interleukin-2 secretion
√ decreased susceptibility to autoimmune diabetes
√ √ increased autoantibody level
√ rheumatoid arthritis
√ decreased susceptibility to parasitic infection
√ increased susceptibility to viral infection
√ increased length of allograft survival
√ √ abnormal liver physiology
√ √ increased sensitivity to induced morbidity/mortality
√ √ rheumatoid arthritis
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