抑郁和反社会可通过精子遗传，但我们仍能被积极治愈“逆天改命”

创伤与治愈

近年来的研究表明，由于DNA中表观遗传信息的改变，精神创伤是可以遗传的。但是，研究人员最近揭示了这个故事的新副本：

“精神创伤的影响能遗传给后代，但这一过程也能被积极的经历所逆转。”苏黎世大学（University of Zurich）神经表观遗传学教授伊莎贝尔·芒叙（Isabelle Mansuy）说道。

她和同事研究了出生后与母亲分离的新生雄性小鼠，母子均因此遭受了精神上的创伤，这些雄性小鼠和它们的雄性后代都表现出了创伤症状，让它们区别于没有经历母子分离的小鼠。但是，当这些有着创伤症状的小鼠接触到积极体验时，它们的行为发生了转变，后代命运也因此重写。

“我们发现，如果遭受过精神创伤的父辈随后被积极乐观的环境治愈着，那么创伤导致的抑郁行为、认知问题、反社会表现、冒险……[查看全文]

Traces of Genetic Trauma Can Be Tweaked

In recent years researchers have learned that trauma can be inherited—passed down due to changes in DNA, what's known as epigenetics. But researchers recently uncovered a new wrinkle to the story:

'The effects of trauma which can be transmitted to the offspring can be reversed by a positive experience.'

That's Isabelle Mansuy, professor of neuroepigenetics at the University of Zurich.

She and colleagues studied newborn male mice and their mothers that were separated from each other, which caused them both to experience traumatic stress. Those male mice and their male offspring displayed trauma symptoms—which made them different from other mice that had not been separated from their mothers. But when these symptomatic mice were exposed to positive experiences, their behavior changed—as did the fate of their offspring.

'And we show that the negative consequences of this which are depressive behaviors, cognitive problems, antisocial behaviors, risk...[full transcript]

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