内科学 | 心力衰竭病理生理

Frank-Starling 定律

Cardiac function curve In diagrams illustrating the Frank–Starling law of the heart, the y-axis often describes the stroke volume, stroke work, or cardiac output. The x-axis often describes end-diastolic volume, right atrial pressure, or pulmonary capillary wedge pressure. The Frank-Starling mechanism occurs as the result of the length-tension relationship observed in skeletal muscles. As a muscle fiber is stretched, active tension is created by altering the overlap of thick and thin filaments. The greatest isometric active tension is developed when a muscle is at its optimal length. In most relaxed skeletal muscle fibers, passive elastic properties maintain the muscle fibers length near optimal.

心室舒张末期容积在一定范围内增大可增加心室收缩力

In contrast, the normal point of cardiac muscle cells, in a resting individual, is lower than the optimal length for contraction.In the human heart, maximal force is generated with an initial sarcomere length of 2.2 micrometers, a length which is rarely exceeded in a normal heart. Initial lengths larger or smaller than this optimal value will decrease the force the muscle can achieve. 

心室肌具有抗过度延伸特性

 思维导图—心力衰竭病理生理

心力衰竭病理生理

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