论文标题：Vitamin D regulates microbiome-dependent cancer immunity
作者：Evangelos Giampazolias, Mariana Pereira da Costa, Khiem C. Lam, Kok Haw Jonathan Lim† , Ana Cardoso, Cécile Piot, Probir Chakravarty, Sonja Blasche, Swara Patel, Adi Biram, Tomas Castro-Dopico, Michael D. Buck, Richard R. Rodrigues, Gry Juul Poulsen, Susana A. Palma-Duran, Neil C. Rogers, Maria A. Koufaki, Carlos M. Minutti, Pengbo Wang, Alexander Vdovin
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期刊：Science
发表时间：2024/04/25
数字识别码：10.1126/science.adh7954
摘要：A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.
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摘要翻译（由计算机程序完成，仅供参考，内容以英文原文为准）：
维生素D在免疫调节和癌症中的作用已被提出。在这项工作中，我们报告说，维生素D可用性增加的小鼠对可移植癌症表现出更大的免疫依赖性耐药性，并对检查点阻断免疫疗法的反应增强。同样，在人类中，维生素D诱导的基因与免疫检查点抑制剂治疗反应的改善以及对癌症的免疫力和总生存率的提高相关。在小鼠中，耐药性可归因于维生素D对肠上皮细胞的活性，这会改变微生物组组成，有利于；脆弱拟杆菌，积极调节癌症免疫力。我们的研究结果表明，维生素D、微生物共生群落和对癌症的免疫反应之间存在着以前未被重视的联系。总的来说，他们强调维生素D水平是癌症免疫和免疫疗法成功的潜在决定因素。
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