细胞自噬研究必看的经典综述（含下载链接）

细胞自噬是2016年诺奖获奖理由，今年的国自然基金公布结果也证实了自噬与各科研热点的结合以及与疾病的关系，公众号前期写过一些文章，大家可看：

• 国科金写作，选题自噬的N种可能性……

• 自噬研究不得不了解的分子通路及数据库

• 国科金lncRNA和自噬，两个热点应该怎么串？
  

• 自噬 AMPK信号通路文章解读

今天我们来为大家推荐细胞自噬研究需要看的经典综述，文章尽量照顾到各个领域的研究，文末是综述文章的下载链接。

1. 以细胞自噬为靶点的肿瘤治疗：Targeting autophagy in cancer.Nat Rev Cancer. 2017 Sep;17(9):528-542. 

Autophagy can be inhibited at multiple stages.

2. 细胞自噬与风湿性疾病：Autophagy: controlling cell fate in rheumatic diseases.Nat Rev Rheumatol. 2016 Sep;12(9):517-31.

Dysregulation of autophagy alters cell fate in rheumatic diseases

3. 细胞自噬在神经退行性疾病的发病和治疗中的角色：Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.Neuron. 2017 Mar 8;93(5):1015-1034. 

Intersections between Autophagy and Disease-Associated Genes

4. 自噬起始和终止的分子机制：Emerging Mechanisms in Initiating and Terminating Autophagy.Trends Biochem Sci. 2017 Jan;42(1):28-41.

Temporal Regulation of Autophagy Response in Nutrient Starvation. 

5. 激活自噬促进免疫化疗和放疗：Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy.Nat Rev Clin Oncol. 2017 Apr;14(4):247-258.

Dominance of the cell-extrinsic effects of autophagy.

6. 自噬与炎症因子信号通路：Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.Nat Rev Immunol. 2016 Nov;16(11):661-675.

Crosstalk between Toll-like receptor and NOD-like receptor signalling and autophagy. 

Intersection between autophagy and cytokines

7. 植物里的自噬：Autophagy in Plants--What's New on the Menu?Trends Plant Sci. 2016 Feb;21(2):134-44. 

Plant Cargo Receptors and the Pathways in which They Act

8.表观遗传学与细胞自噬的关系：Epigenetic Control of Autophagy: Nuclear Events Gain More Attention.Mol Cell. 2017 Mar 2;65(5):781-785. 

Histone Modifications and Epigenetic Enzymes Linked to the Regulation of Autophagy

9.蛋白泛素化修饰和自噬：The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.Trends Biochem Sci. 2017 Nov;42(11):873-886. 

Role of Ubiquitin (Ub) Linkages in Protein Quality Control. 

10. 药物治疗自噬：Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.Nat Rev Drug Discov. 2017 Jul;16(7):487-511.

Autophagic processes amenable to therapeutic modulation

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