早读：成人常见弥漫性胶质瘤分类的简化

Simplification of the classification of common adult-type diffuse gliomas	成人常见弥漫性胶质瘤分类的简化
In the 2016 WHO classification of CNS tumours, the common diffuse gliomas of adults were divided into 15 entities, largely because different grades were assigned to different entities (e.g. anaplastic oligodendroglioma was considered a different type from oligodendroglioma) and because NOS designations were assigned to distinct entities (e.g. diffuse astrocytoma NOS）.	在2016年世界卫生组织的中枢神经系统肿瘤分类中，成年人常见的弥漫性胶质瘤被分为15个实体，主要是因为不同的实体被分为不同的级别（例如，间变性少突胶质瘤被认为是与少突胶质瘤不同的类型），并且因为NOS被分为不同的实体（例如，弥漫性星形细胞瘤NOS）。
In contrast, this fifth edition includes only three types: astrocytoma, IDH-mutant; oligodendroglioma, IDH-mutant and 1p/19q codeleted; and glioblastoma, IDH-wildtype.	相比之下，第五版只包括三种类型：星形细胞瘤、IDH突变型；少突胶质瘤、IDH突变和1p/19q基因共缺失型；胶质母细胞瘤，IDH野生型。
This focusing of the classification has resulted from (1) more ecumenical use of the designations “not otherwise specified (NOS）” and “not elsewhere classified (NEC）”, as discussed in the general introduction to this volume and in cIMPACT update 1; (2)recognition of the value of molecular diagnostics to assign older entities (e.g. oligoastrocytoma or IDH-wildtype diffuse astrocytoma) to more objectively defined types; and (3) use of grades within types rather than requiring each grade to have a different name.	这种对分类的关注源于（1）更普遍地使用“非特指（NOS）”和“未另行分类（NEC）”，如本卷的一般介绍和cIMPACT更新1中所述；（2） 认识到分子诊断的价值，将较老的实体（如少突星形细胞瘤或IDH野生型弥漫性星形细胞瘤）分为更客观定义的类型；（3）在类型中使用等级，而不是要求每个等级有不同的名称。