中药中天然类固醇—胆固醇肉豆蔻酸酯

胆固醇肉豆蔻酸酯相关参数说明：

CAS Registry No.: 1989-52-2

Formal Name: (3β)-cholest-5-en-3-ol 3-tetradecanoate

Synonyms: Cholesterol Myristate, Cholesteryl Tetradecanoate, Myristic Acid cholesteryl ester, NSC 226867

MF: C41H72O2

FW: 597.0

Purity: ≥98%

Supplied as: A crystalline solid

Storage: -20°C

Stability: ≥2 years

胆固醇肉豆蔻酸酯实验室程序：

Cholesteryl myristate is supplied as a crystalline solid. A stock solution may be made by dissolving the cholesteryl myristate in the solvent of choice. Cholesteryl myristate is soluble in the organic solvent chloroform, which should be purged with an inert gas, at a concentration of approximately 10 mg/ml.

胆固醇肉豆蔻酸酯相关描述：

Cholesteryl myristate is a cholesterol ester.1 Levels of cholesteryl myristate are increased in the serum, liver, and aorta in rabbits fed a high-cholesterol diet and positively correlate with development of non-alcoholic fatty liver disease (NAFLD). Plasma levels of cholesteryl myristate also positively correlate with the presence of unstable atherosclerotic plaques in coronary artery disease.2 Cholesterol myristate has been used in the composition of lipid nanoparticles (LNPs) as a drug carrier systems for drugs with low water solubility.3

文献参考：

1.Kim, E.J., Kim, B.H., Seo, H.S., et al. Cholesterol-induced non-alcoholic fatty liver disease and atherosclerosis aggravated by systemic inflammation. PLoS One 5(6), e97841 (2014).

2.Meikle, P.J., Wong, G., Tsorotes, D., et al. Plasma lipidomic analysis of stable and unstable coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 31(11), 2723-2732 (2011).

3.Rosenblatt, K.M. and Bunjes, H. Evaluation of the drug loading capacity of different lipid nanoparticle dispersions by passive drug loading. Eur. J. Pharm. Biopharm. 117, 49-59 (2017).