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还没发论文?2020年医学生信分析有这些!

Hello,各位小伙伴们,我们是科研菌!!

'科研菌'团队每天为您提供高质量的原创科研论文精读, 期刊投稿, 资源分享和文章;每天一篇文章深度剖析,给您更开阔的科研思路。

关注科研菌回复'1'即可获取'28G全网最全科研绘图素材'、'谷歌上网助手'(梯子)'和'科研常用软件合集'、“肿瘤/消化内科指南”、'考研复试大礼包';回复2020,可获得2020年生信套路合集;回复“单细胞文献”,可获得单细胞文献合集以上资源均(无需转发/集赞)

天科研菌为大家带来2020年生信套路合集,一起看下Outline吧

公众号后台回复2020即可获得科研菌2020年最新生信套路合集PDF版!

点击下方任一链接,即可跳转该文章的详细解读!!


一. 生信友好杂志详解

1.被“灌水”的Aging(IF=5.515)还能不能投?

带你了解 ①Aging现在的状况如何?②Aging成了纯生信灌水的乐园?

2.即将突破5分的Frontiers in Oncology是灌水杂志吗?

带你了解 ①Front Oncol发表的生信文章的文章类型为哪几类?②纯生信文章的发表周期如何?

3.马上4分年刊近2000的杂志JCB:对纯生信友好还不要版面费!

一文速览 ①JCB的纯生信文章分类 ②投稿建议

4.年刊量3000篇预计5+分的JCP

一文速览 ①JCP的投稿类型范围 ②纯生信文章分类 ③投稿周期

5.推荐一本生信友好并且最快1月接受的5+分杂志

二.生信思路详解

1.如何筛出一篇5分文章的核心基因

①数据集筛选原则 ②举例(Case1:肿瘤预后基因; Case2:Risk Score; Case3:耐药基因)


2.筛到5分的核心基因以后你可以怎么做?

①Case1:预后标志物+免疫浸润; ②Case2:单基因多组学验证生存; ③Case3:基因突变+TMB+免疫浸润


3.国自然前期研究基础不足?你可以这样补一些生信分析

①理清研究方向 ②举例 ③生信分析注意事项 


4.非肿瘤生信分析:来不及解释了快上车!

①GEO数据库是什么呢?

②GEO数据库里有多少非肿瘤的数据呢?

③非肿瘤生信GEO的数据挖掘有什么获益呢?

④入门GEO数据挖掘你需要做什么呢?

⑤在线分析网站推荐+生信数据库合集推荐+生信扩展工具合集推荐 


三.生信文章详解(标志物&分型&建模)

常规转录组类

(一)表达谱预后

胶质瘤双基因预后标志物就能3+了?

A robust two‐gene signature for glioblastoma survival prediction


肾癌之自噬基因预后预测模型发5+分

Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma 


肾癌EMT基因预后标志物发5+分

Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinomae


9+纯生信泛癌预后标志物筛选

Landscape of cancer diagnostic biomarkers from specifically expressed genes

 

纯生信新套路:肺鳞癌TP53基因signature

A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma

5分+的单基因综合分析还几乎零代码

Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities

(二)肿瘤免疫微环境或免疫相关类

围观:为什么别人的免疫浸润能发9+分?

Immune cell infiltration-based signature for prognosis and immunogenomic analysis in breast cancer

 


5+易学套路: 基因突变+TMB+免疫浸润

EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients


纯生信4+膀胱癌免疫微环境思路分享

Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics

 

单基因结合免疫浸润的新思路

Immune-related keygene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma

一看就会的3+典型免疫浸润表型

Immune gene expression profiling reveals heterogeneity in luminal breast tumors

Nat Commun: 肿瘤淋巴细胞浸润算法预测黑色素瘤生存

An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma


一学就会的5+分免疫基因与乳腺癌异质性分析

Immune gene expression profiling reveals heterogeneity in luminal breast tumors

 


(三)ceRNA

膀胱癌ceRNA的3+分思路

Identification of the Key Factors Related to Bladder Cancer by lncRNA-miRNA-mRNA Three-Layer Network

别人的膀胱癌ceRNA如何做出新花样?

Identification of a potentially functional circRNA–miRNA–mRNA regulatory network for investigating pathogenesis and providing possible biomarkers of bladder cancer

三张图的miRNA简单分析如何发6分?

Model-Based Integration Analysis Revealed Presence of Novel Prognostic miRNA Targets and Important Cancer Driver Genes in Triple-Negative  Breast Cancers


单细胞转录组类

在Aging上发表的胃癌单细胞测序做了什么?

Single-cell RNA sequencing of immune cells in gastric cancer patients 


仅3个单细胞测序样本纯分析也发6分!

Single-cell RNA sequencing of human kidney


纯生信新冠思路:单细胞测序分析口腔粘膜ACE2表达

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa 

Nat Commun:乳腺癌单细胞测序深度解析

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

Nat Med:一个病例带你了解单细胞测序如何指导临床治疗

Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report


表观遗传类

(一)m6A

15+分的纯生信:胃癌m6A和肿瘤免疫微环境

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

易学版m6A:肾癌预后和机制分析

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer


(二)甲基化

5+乳腺癌表观遗传深度剖析

Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype

干湿结合类

干湿结合上6+高渗基因与透明细胞肾癌预后

Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival


干湿结合的miRNA调控网络发7+也不难

A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

lncRNA简配版干湿结合发5+分

The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

肿瘤学套路如何逆袭JCSM10+顶刊

Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia


基因组类

Genome Med一文带你学会胚系突变与泛癌预后思路

The pan-cancer landscape of prognostic germline variants in 10,582 patients


一文就懂子宫内膜癌的POLE突变如何发病理学顶刊

Interpretation of somatic POLE mutations in endometrial carcinoma

JTO:日本非吸烟肺癌患者基因组综合分析

Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers

2020年的可变剪切有什么不一样?

Profiles of prognostic alternative splicing signature in hepatocellular carcinoma

单基因分析新思路:联合ChIP-Seq

NR2F2 Orphan Nuclear Receptor is Involved in Estrogen Receptor Alpha-Mediated Transcriptional Regulation in Luminal A Breast Cancer Cells

非肿瘤生信类

非肿瘤纯生信:STAT1和结核感染的机制挖掘

STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection

科研菌始终都在,陪你度过漫漫科研路

希望志同道合的小伙伴就像科研“菌”一样不断裂变,越来越多

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