药物背景介绍
安罗替尼是一种新型的口服多靶点抗血管生成酪氨酸激酶抑制剂,在中国已被批准用于晚期非小细胞肺癌的三线和小细胞肺癌的三线治疗。除此,在肉瘤、甲状腺癌、肝癌、乳腺癌、妇瘤等多个癌种中都有数据。依靠抗血管和抑制肿瘤生长的多靶点治疗机制,成为了很多癌种后线的治疗选择。也是化疗、靶向以及免疫的好搭档。
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案例一
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案例二
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案例三
01
拨开迷雾 泛癌种靶点TP53或成为抗血管生成药物的预测因子
02
TP53在多癌种抗血管生产药物治疗中体现很好的预测作用
参考文献
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[4]Wheler JJ, Janku F, Naing A, et al. TP53 alterations correlate with response to VEGF/VEGFR inhibitors: implications for targeted therapeutics. Mol Cancer Ther. 2016;15(10):2475–2485. doi:10.1158/ 1535-7163.MCT-16-0196
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[7]Wu Y, Huang J, Wang Q, et al. Whole-exome sequencing insights into pulmonary artery sarcoma mimicking pulmonary embolism: a case report and review. Onco Targets Ther. 2019;12:6227–6235. doi:10.2147/OTT.S212416
[8]Ruan X, Shi X, Dong Q, et al. Antitumor effects of anlotinib in thyroid cancer. Endocr Relat Cancer. 2019;26(1):153–164. doi:10.1530/ERC-17-0558
[9]Kaushik AC, Wang YJ, Wang X, Wei DQ. Irinotecan and vandetanib create synergies for treatment of pancreatic cancer patients with concomitant TP53 and KRAS mutations [published online ahead of print, 2020 Jul 31]. Brief Bioinform. 2020;bbaa149. doi:10.1093/bib/bbaa149
[10]Graziano F, Fischer NW, Bagaloni I, et al. TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy. Cancers (Basel). 2020;12(8):E2049. Published 2020 Jul 24. doi:10.3390/cancers12082049
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