WI-38 senescence is associated with global and site-specific hypomethylation.
|核心内容：
细胞衰老在器官和器官系统与年龄相关的功能衰退以及与年龄相关的病理(如癌症)中起着重要作用。
因此，更好地了解其潜在的分子机制对于寻找干预措施至关重要。
Figure 1. Reduced protein levels of DNMT1 correlate with decreased global DNA methylation
在这项研究中，我们考虑了DNA甲基化在衰老中的作用。
我们发现衰老与整体DNA低甲基化有关，但也涉及特定部位的DNA低甲基化和高甲基化。
Figure 2. Changes in DNA methylation pattern insenescent cells.
在某些情况下，这种差异甲基化可能会影响基因表达，从而调节细胞内的功能过程。
然而，大多数差异甲基化的CpG位点并不对应于基因表达的改变，这表明DNA甲基化还通过其他方式影响衰老，例如基因组的稳定性。
原文摘要：
Cellular senescence plays an important role in the age-dependent functional decline of organs and organ systems, as well as in age-related pathologies, such as cancer. Therefore, a better understanding of its underlying molecular mechanisms is crucial in the search for intervening measures. In this study, we considered the role of DNA methylation in senescence. We found that senescence is associated with global DNA hypomethylation, but also involves site-specific DNA hypo- and hypermethylation. In some cases, this differential methylation may affect gene expression and thereby modulate functional processes within cells. However, the majority of the CpG sites that were differentially methylated did not correspond with altered gene expression, suggesting that DNA methylation affects senescence by other means also, such as, for instance, genome stability.
参考文献：http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4153623&blobtype=pdf
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