Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
模仿禁食的饮食可以防止高脂肪饮食对心脏代谢风险和寿命的影响
|核心内容：
饮食诱导的肥胖是代谢综合征、糖尿病和心血管疾病的主要危险因素。
在这里，我们发现了5天的模拟禁食饮食(FMD)，每4周进行一次，为期2年，可以改善雌性小鼠摄入高脂肪、高热量饮食(HFCD)所引起的有害变化。
我们证明，每月的FMD周期通过减少内脏和皮下脂肪的积累来抑制HFCD介导的肥胖，而不导致瘦体重的损失。
FMD周期增加心脏血管供应、功能和对心脏毒素的抵抗，预防HFCD依赖性高血糖、高胆固醇血症和高瘦素血症，并改善葡萄糖和胰岛素耐量受损。
每月FMD周期对脂肪细胞线粒体代谢和生物发生相关基因表达的影响以及HFCD喂养小鼠持续生酮的影响表明脂肪细胞重编程在预防肥胖中的作用。
FMD对肥胖和心脏衰老的这些影响可以解释对HFCD依赖的早期死亡率的保护。
The FMD increases longevity and limits body fat accumulation and weight gain
原文摘要：
Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease.
Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice.
We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass.
FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and insulin tolerance.
The effect of monthly FMD cycles on gene expression associated with mitochondrial metabolism and biogenesis in adipocytes and the sustained ketogenesis in HFCD-fed mice indicate a role for fat cell reprogramming in obesity prevention.
These effects of an FMD on adiposity and cardiac ageing could explain the protection from HFCD-dependent early mortality.
参考文献：Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
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