2016年6月13日，德国《Small》杂志在线发表中国国家纳米科学中心、中国中医科学院中药研究所、首都医科大学生物医学工程学院的研究报告，发现多孔基质刚度可以调控靶向疗法效果。多孔基质多孔弹性行为可以调控细胞-基质和细胞-细胞相互作用分子事件，如人表皮生长因子受体2（HER2）-Src-α6β4整联蛋白复合物形成，影响拉帕替尼靶向疗法。
Small. 2016 Jun 13. [Epub ahead of print]
Porous Matrix Stiffness Modulates Response to Targeted Therapy in Breast Carcinoma.
Liu C, Li X, Hua W, Li J, Han X, Ha Q, Feng J, Liao F, Li D, Han D.
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, P. R. China; Institute of Biomedical Engineering, Capital Medical University, Beijing, 100069, P. R. China.
Porous matrix stiffness modulates response to targeted therapy. Poroelastic behavior within porous matrix may modulate the molecule events in cell-matrix and cell-cell interaction like the complex formation of human epidermal growth factor receptor-2 (HER2)-Src-α6β4 integrin, influencing the targeted therapy with lapatinib.
KEYWORDS: biomechanopharmacology; human epidermal growth factor receptor-2; porous matrix; stiffness; targeted therapy
PMID: 27295361
DOI: 10.1002/smll.201601365
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