抗精神病药物可能提高阿尔茨海默病患者早期死亡的风险

研究表明，如果服用两种抗精神病药物，几率增加几乎翻倍

研究人员分析了2005年至2011年间芬兰被诊断为阿尔茨海默病的近58,000人的数据。

阿尔茨海默病患者中稍多于1/4的患者会服用抗精神病药物。研究发现那些服药者比没有服用这些药物的死亡风险高60％。

当患者首次服用抗精神病药物时死亡风险是最高的，但是持续长期服用该类药物死亡风险会随之增加。

同时服用两种或更多种抗精神病药物的患者比只服用一种抗精神病药物的患者早期死亡的风险要高出一倍。

虽然研究发现抗精神病药物使用和更高的死亡风险之间的关联，但研究并不能证明他们的因果关系。

但是，由东芬兰大学药学院的Marjaana Koponen博士带领的研究人员说，他们的发现支持以前的研究。有关服用抗精神病药物增加阿尔茨海默病患者的死亡风险的首次警示是在10多年前发布的。

研究人员说，这项新研究证实了当前的建议，抗精神病药物应该仅用于痴呆病人最困难的行为症状，如激惹和攻击行为，并且使用时间应该是短期的。

此外，应尽可能给予患者最低剂量，并且不应同时给予两种或更多种抗精神病药。

此项研究近期发表于Journalof Alzheimer's Disease

翻译：袁波

附：

AntipsychoticDrugs May Up Risk of Early Death in Alzheimer's Patients

Increased odds were nearly doubled if two antipsychotic medications were taken, studysays

By Robert Preidt

Tuesday,December 27, 2016

TUESDAY,Dec. 27, 2016 (HealthDay News) -- Taking antipsychotic drugs significantly increases the risk of premature death among Alzheimer's patients, a new studyindicates.

Researchers analyzed data from almost 58,000 people in Finland diagnosed with Alzheimer'sdisease between 2005 and 2011.

Slightly more than a quarter of the Alzheimer's patients took antipsychotic drugs. Thestudy found they had a 60 percent higher risk of death than those who didn'ttake the drugs.

Therisk of death was highest when patients first started taking antipsychotics,but the increased risk persisted with long-term use of the drugs.

Patients who took two or more antipsychotic drugs at the same time were nearly twice aslikely to die early than those who took one antipsychotic.

Although the study found an association between antipsychotic drug use and a higher riskof dying, it cannot prove a cause-and-effect link.

But,the researchers -- led by Marjaana Koponen, a doctoral student from the School of Pharmacy at the University of Eastern Finland -- said their findings supportprevious studies. The first warnings about increased risk of death among Alzheimer's patients taking antipsychotics were issued more than 10 years ago.

The new study confirms current recommendations that antipsychotic drugs should be used only for the most difficult behavioral symptoms of dementia, such as agitationand aggression, and that length of use should be limited, the researchers said.

Also,patients should be given the lowest possible doses, and should not be given twoor more antipsychotics at the same time.

Thestudy was published recently in the Journal of Alzheimer's Disease.

关爱父母 关注阿尔茨海默病

阿默科技官方服务号