题目：Expression and prognosis analyses of forkhead boxA (FOXA) family in human lung cancer（ doi: 10.1016/j.gene.2018.11.022）
摘要：
Despite advances in early diagnosis and treatment, cancer still remainsthe major reason of mortality worldwide. The forkhead box A (FOXA) family isreported to participate in diverse human diseases. However, little is knownabout their expression and prognostic values in human lung cancer. Herein, weconducted a detailed cancer vs. normal analysis. The mRNA expression levels of FOXAfamily in numerous kind of cancers, including lung cancer, were analyzedusing the Oncomine and GEPIA database. We observed that the mRNAexpression levels of FOXA1, and FOXA3 were all increased while FOXA2 weredecreased in most cancers compared with normal tissues, especially in lung cancer. Moreover, theexpression levels of FOXA1, and FOXA3 are also highly expressed, while FOXA2were decreased in almost all cancer cell lines,particularly in lung cancer cell lines, analyzing by Cancer Cell LineEncyclopedia (CCLE) and EMBL-EBI databases. Furthermore, the LinkedOmicsdatabase was used to evaluate the prognostic values, indicating that higherexpression of FOXA1, FOXA3 indicated a poor overall survival (OS), whileincreased FOXA2 revealed a better OS in lung cancer. To conclusion,FOXA family showed significant expression differences between cancer and normaltissues, especially lung cancer, and FOXA1, FOXA3could be promising prognostic biomarkers for lung cancer.
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