每天朗读一段医学影像学英语文章
Progressive systemic sclerosis is characterized by atrophy and sclerosis of many organ systems, including the skin, musculoskeletal system, and heart as well as the lungs.
进行性系统性硬化症以多器官系统萎缩、硬化为特点，可累及皮肤、肌骨系统、心脏和肺。
The basic pulmonary lesion is interstitial fibrosis, which may take the form of a fine reticular pattern that becomes more coarse and dense as the disease progresses, eventually producing a reticulonodular pattern.
肺部基本病变为肺间质纤维化。随着病情进展，病灶可由规则的网状影变成粗糙的高密度影，最终出现网状结节影。
Characteristically, lung volumes are diminished with a basilar and peripheral distribution of disease with or without honeycombing. HRCT is the method of choice for evaluating early parenchymal involvement and include ground-glass opacity, honeycombing, bronchiectasis, septal and pleural thickening, and subpleural cysts. The radiographic pattern is often that of usual interstitial pneumonitis, although histopathologic patterns of usual interstitial pneumonitis or nonspecific interstitial pneumonitis may be found.
典型的特点是，肺容量下降，病灶沿肺基底或外周播散，伴或不伴蜂窝化。HRCT是评估肺实质早期受累的最佳检查方式，相关影像表现有磨玻璃影、蜂窝影、支气管扩张、小叶间隔和胸膜增厚、胸膜下囊肿。影像分型中，常为普通型间质性肺炎（UIP），组织病理学分型中，普通型间质型肺炎或非特异性间质性肺炎（NSIP）均可见。
Esophageal dilatation may be seen on CT in up to 80% of patients with progressive systemic sclerosis. When the esophagus is involved, aspiration into the basal segments of lung may also account for the radiographic abnormalities.
进行性系统性硬化症患者的CT检查中，约80%可见食管扩张。当食管受累时，肺基底段的针吸活检可对异常的影像表现作出解释。
Notes:
1. sclerosis [skləˈroʊsɪs] n. 硬化症
2. atrophy [ˈætrəfi] n. 萎缩，衰退
3. interstitial [ˌɪntərˈstɪʃl] adj. 填隙; 空隙的
4. reticular [rɪ'tɪkjələ] adj. 网状的
5. peripheral [pəˈrɪfərəl] adj. 外围的; 次要的
6. parenchymal [pə'rəŋkəməl] 实质的，主质的，薄壁组织的
7. bronchiectasis [brɑŋkɪ'ektəsɪs] n. 支气管扩张
8. septal ['septəl] adj. 隔膜的
9. pleural ['plʊərə] adj. 胸腔; 胸膜的
10. pneumonitis [ˌnju:mə'naɪtɪs] n. 局限性肺炎，肺炎
11. esophagus [aɪˈsɑfəɡəs] n. 食管，食道
12. dilatation [ˌdɪləˈteʃən, ˌdaɪlə-] n. 膨胀; （中空器官或空洞）扩张
来源：每天朗读一段医学影像学英语文章
圈主
深圳市人民医院放射科副主任医师杨敏洁
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