简介:他扎罗汀,Tazarotene是选择性视黄酸受体 (RAR) 激动剂,用于治疗斑块状银屑病和寻常痤疮。
物理化学性质:
密度
1.2±0.1 g/cm3
沸点
499.8±45.0 °C at 760 mmHg
熔点
97-98ºC
分子式
C21H21NO2S
分子量
351.462
闪点
256.1±28.7 °C
精确质量
351.129303
PSA
64.49
LogP
6.22
外观性状
白色固体
蒸汽压
0.0±1.3 mmHg at 25°C
折射率
1.625
储存条件
Store at +4°C
详细介绍:
中文名称:
他扎罗汀
中文别名:
他扎罗汀;6-[2-(4,4-二甲基二氢苯并噻喃-6-基)乙炔基]吡啶-3-甲酸乙酯;Tazarotene 他扎罗汀;他扎罗汀标准品;他扎罗汀杂质
英文名称:
Tazarotene
英文别名:
Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;TAZAROTENE;agn190168;6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-pyridinecarboxylic Acid Ethyl Ester;Tazorac;Zorac;6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran)-6-yl]nicotinic acid ethyl ester;ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate;6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester;AGN-190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate;Ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate;Avage;Tazarotene(Avage);Fabior;Tazarotene [USAN:INN];AGN 190168;Tazarotene (Avage);Zora;C21H21NO2S;81BDR9Y8PS;OGQICQVSFDPSEI-UHFFFAOYSA-N;3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester;ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)et
CAS号:
118292-40-3
分子式:
C21NO2SH21
分子量:
351.46
详细描述:
Medlife,致力于提供高品质、高性价比小分子化合物的产品。
小分子化合物大量库存,提供超过2万种的抑制剂、激动剂、拮抗剂等产品,是药物及疾病研究的重要原料供应商。
外用视黄酸、抗增殖、TIG3肿瘤抑制剂的诱导物,Tazarotene是选择性视黄酸受体 (RAR) 激动剂,用于治疗斑块状银屑病和寻常痤疮。
参考文献:
[1]. Talpur R,et al. Efficacy and safety of topical tazarotene: a review. Expert Opin DrugMetab Toxicol. 2009 Feb;5(2):195-210.
[2]. Nagpal S,et al. Negative regulation of two hyperproliferative keratinocytedifferentiation markers by a retinoic acidreceptor-specific retinoid: insightinto the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996Dec;7(12):1783-91.
[3]. Tang-LiuDD, et al. Clinical pharmacokinetics and drug metabolism of tazarotene: a noveltopical treatment for acne and psoriasis. Clin Pharmacokinet. 1999Oct;37(4):273-87.
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