通常,从药物研发到普通药品上中须经过以下几个过程:
①研发筛选(R&D Screening),包括市场调查(Market Survey)与专利调查(Patent Survey):
②临床前研究(Preclincal Studies):
③临床阶段(Clinical Phases):
④新药批准上市(New Drug Approva):
这几个过程背后要经历上几百万道工序最后才能上市,背后数据的查找、筛选、对比。。。。
需要处理的数据庞大,一个医药全生命周期的数据库必不可少。
药融云医药数据库V4.0包含了医药全生命周期数据库群涵盖了70+国家地区,采集近200个数据库。
近百个维度搜索-全类目关联-数据可视化图表。
(附)非付费医药数据相关网址平台网站5类50个
疾病类
①NCBI - National Center for BiotechnologyInformation
网址:http://www.ncbi.nlm.nih.gov/
②COSMIC-Catalogue Of Somatic Mutations In Cancer
网址:http://cancer.sanger.ac.uk
网址:http://www.informatics.jax.org/
④HGMD-The Human Gene Mutation Database
网址:http://www.hgmd.org
网址:http://www.human-phenotype-ontology.org/
⑥CTD-Comparative Ttoxicogenomics Database
网址:http://ctdbase.org/
⑦Atlasof Genetics and Cytogenetics in Oncology and Haematolog
网址:http://atlasgeneticsoncology.org/
网址:http://www.mir2disease.org/
⑨PlasmoDB-Plasmodium Genomics Resourse
网址:http://plasmodb.org/plasmo/
网址:http://www.disease-ontology.org/
1. KEGG -Kyoto Encyclopedia of Genes and Genomes
网址:http://www.kegg.jp/
2. HMDB -The Human Metabolome Database
网址:http://www.hmdb.ca/
3. Reactome- A Curated Pathway Database
网址:http://www.reactome.org/
网址:http://www.phosphosite.org/
5. EcoCyc- BioCyc Database Dollection
网址:http://ecocyc.org/
6. APD -Antimicrobial Peptide Database
网址:http://aps.unmc.edu/AP/main.php
7. REBASE-The Restriction Enzyme Database
网址:http://rebase.neb.com/
8. PathwayCommons - Search and visualize public biological pathway information
网址:http://www.pathwaycommons.org/about/
9. PID -Patheay Interaction Database
网址:http://pid.nci.nih.gov/
10. TAIR - The Arabidopsis Information Resource
网址:https://www.arabidopsis.org/
1. UniProt- The Universal Protein Resource
网址:http://www.uniprot.org/
2. Pfam -Protein Families Database
网址:http://pfam.xfam.org/
网址:http://www.ensembl.org/
4. STRING- Known and Predicted Protein-Protein Iinteractions
网址:http://string-db.org/
5. UCSCGenome Browser - University of California,Santa Cruz Genome Browser
网址:http://genome.ucsc.edu/
6. NCBI -National Center for Biotechnology Information
网址:http://www.ncbi.nlm.nih.gov/
7. PROSITE- Database of protein domains,families and functional sites
网址:http://prosite.expasy.org/
8. BioGRID- Biological General Repository for Interaction Datasets
网址:http://thebiogrid.org/
9. InterPro- Protein sequence analysis & classification
网址:http://www.ebi.ac.uk/interpro/
网址:http://www.proteomexchange.org/
网址:http://www.mirbase.org/
网址:http://www.ensembl.org/
3. RDP -Ribosomal Database Project
网址:http://rdp.cme.msu.edu/
4. UCSCGenomes Browser - University of California,Santa Cruz Genome Browser
网址:http://genome.ucsc.edu/
5. NCBI -National Center for Biotechnology Information
网址:http://www.ncbi.nlm.nih.gov/
网址:http://rfam.xfam.org/
7. TRANSFAC- a database on transcription factors and their DNA binding sites
网址:http://www.gene-regulation.com/pub/databases.html
8. FlyBase- Database of Drosophila Genes & Genomes
网址:http://flybase.org/
9. RefSeq- Reference Sequence Database
网址:http://www.ncbi.nlm.nih.gov/refseq/
10. miRTarBase - miRNA Target Database
网址:http://mirtarbase.mbc.nctu.edu.tw/
1. Pfam -Protein Families Database
网址:http://pfam.xfam.org/
2. ChEMBL
网址:https://www.ebi.ac.uk/chembl/
3. CDD -Conserved Domain Database
网址:http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml
4. SWISS-MODEL- The SWISS-MODEL Repository
网址:http://swissmodel.expasy.org/repository/
5. CAZy -Carbohydrate-active Enzymes Database
网址:http://www.cazy.org/
6. BRENDA- The Comprehensive Enzyme Information System
网址:http://www.brenda-enzymes.org/
7. CATH
网址:http://www.cathdb.info/
8. RCSBPDB - RCSB Protein Data Bank
网址:http://rcsb.org/
9. DisProt- Database of Protein Disorder
网址:http://www.disprot.org/
10. BMRB - biological magnetic resonance databank
网址:http://www.bmrb.wisc.edu/
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