病史介绍
临床表现
大体所见
镜下形态
图1
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图5
图6
图7
图8
免疫组化结果
最终诊断
讨论
定义
临床特点
发病机理
病理特征
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诊断标准
预后、预测
鉴别诊断
参考:
向上滑动阅览
1、Ioachim's Lymph Node Pathology, 5th edition.
2、Delsol G, Lamant L, Mariamé B, et al. A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation. Blood. 1997 Mar;89(5):1483-90.
3、Onciu M, Behm FG, Downing JR, et al. ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood. 2003 Oct;102(7):2642-4.
4、Stachurski D, Miron PM, Al-Homsi S, et al. Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24. Hum Pathol. 2007 Jun;38(6):940-5.
5、Laurent C, Do C, Gascoyne RD, et al. Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a rare clinicopathologic entity with poor prognosis. J Clin Oncol. 2009 Sep;27(25):4211-6.
6、Rossky PJ, Walker GC. Retrospective. Paul F. Barbara (1953-2010). Science. 2010 Nov;330(6008):1191.
7、Takeuchi K, Soda M, Togashi Y, et al. Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. Haematologica. 2011 Mar;96(3):464-7.
8、Valera A, Colomo L, Martínez A, et al. ALK-positive large B-cell lymphomas express a terminal B-cell differentiation program and activated STAT3 but lack MYC rearrangements. Mod Pathol. 2013 Oct;26(10):1329-37.
作者
高宇慧 住院医师
陕西省西安市红会医院病理科
西临床病理 住培医师
审校
吴建锋 主治医师
附属西病理科
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