1. 两者均可指人，有时可互换（包括当先行词为 all, anyone, someone等，同时也包括先行词受the only等的修饰时）：
All that [who] heard him were delighted. 所有听了他讲话的人都很高兴。
He is the only one among us that [who] knows Russian.他是我们中间唯一懂俄语的人。
Anyone who [that] is over sixteen is allowed in. 任何超过十六岁的人都允许进去。
It is impolite to turn your back on someone who [that] is speaking to you. 人家跟你说话，你把背朝人是不礼貌的。
2. 但是在下列情况，通常要用 that：
①当先行词是一个既指人又指物的并列词组时：
I made a speech on the men and things that I had seen abroad. 我就我在国外所见到的人和事作了报告。
②当先行词是who时(为避免重复)：
Who was it that won the World Cup in 1982? 谁赢得了1982年的世界杯？
③当关系代词在定语从句中作表语时(可省略)：
Tom is not the boy (that) he was. 汤姆这孩子已不是以前那个样子了。
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